ASSAf News

The Academy of Science of South Africa (ASSAf) and the University of Pretoria cordially invite you to a lecture on Birth and Future of Multi-scale Modeling of Macromolecules by Prof Michael Levitt, ASSAf Distinguished Visiting Scholar.

Date:   13 November 2017

Time:     16:30 for 17:00 - Refreshments will be served afterwards. 

Venue:   Engineering 1 Building, Exhibition Space, Hatfield Campus, University of Pretoria

RSVP:   Click here to RSVP by 12:00, Friday, 10 November 2017. Limited space available

ABSTRACT: BIRTH & FUTURE OF MULTI-SCALE MODELING OF MACROMOLECULES

The development of multi-scale models for complex chemical systems began in 1967 with publications by Warshel and Levitt recognised by the 2013 Nobel Committee for Chemistry. The simplifications used then at the dawn of the age of computational structural biology were mandated by computers that were almost a billion times less cost-effective than those we use today. These same multi-scale models have become increasingly popular in applications that range from simulation of atomic protein motion, to protein folding and explanation of enzyme catalysis. In this talk Prof Levitt describes the origins of computational structural biology and then shows some of the most exciting current and future applications.

MORE ABOUT PROF LEVITT

Born in South Africa in 1947, Prof Levitt was awarded the 2013 Nobel Prize for Chemistry (shared with Martin Karplus and Arieh Warshel). Prof Levitt’s diverse interests have included RNA and DNA modelling, protein folding simulation, classification of protein folds and protein geometry, antibody modelling, x-ray refinement, antibody humanisation, side-chain geometry, torsional normal mode, molecular dynamics in solution, secondary structure prediction, aromatic hydrogen bonds, structure databases, and mass spectrometry. His current postdoctoral work on protein evolution, the crystallographic phase problem and Cryo-EM refinement. He has a passion in helping today’s young scientists gain the recognition and indepen-dence that his generation enjoyed.

 


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